研究概况:邦妮肯塔基州, M.D., M.S.C.E.
邦妮肯塔基州, M.D., M.S.C.E., aims to advance precision medicine in cardio-oncology, which is the study of cardiovascular disease in cancer patients. That’s important because even with more modern targeted cancer treatments, patients’ hearts and vascular systems often suffer.
Cardiotoxicity broadly defines cardiovascular injury that occurs with cancer therapies, 据医生说. Ky.
The goals are to have a deep understanding from using advanced imaging, biomarker tools and phenotyping which individual cancer patients are at high risk for cardiotoxicity, why they’re at risk and how to prevent the damage while delivering cancer treatment.
“Through the 美国心脏协会 (AHA) Institute for Precision Cardiovascular Medicine, I’ve been fortunate to obtain funding for a project focusing specifically on using imaging to identify new patterns of cardiotoxicity in breast cancer patients,”医生说。. Ky, associate professor of Medicine and Epidemiology at Penn Medicine.
Dr. Ky and colleagues are using a large dataset of breast cancer patients with detailed echocardiography imaging done at multiple times before, 在癌症治疗期间和之后. The dataset also includes patients’ bloodwork and clinical information. Among the patients in the large data set are women who have had traditional chemotherapy and radiation, as well as highly specific cancer drugs, 如曲妥珠单抗(赫赛汀).
“These agents help breast cancer patients live longer. But they carry a notable risk of cardiotoxicity, 包括心力衰竭, in a growing cancer population of more than 15 million individuals worldwide,”她说。 .
Using the 美国心脏协会’s Precision Medicine Platform, Dr. Ky and colleagues are analyzing the echocardiograms with machine learning strategies, which means they’re harnessing technology and algorithms to detect patterns in imaging that might suggest cardiovascular damage or recovery in heart function. Computer learning technology can accelerate this type of research wit large and diverse datasets.
“Precision medicine will let us move past the one-size-fits-all strategy many providers use to treat cardiovascular patients today,” Dr. 肯塔基州说. “As a specialty, cancer has been doing it for a long time. We want to apply that same paradigm to cardiovascular disease using precision medicine.”
心脏病专家, oncologists and other providers will better understand how an individual patient’s biologic characteristics and genetic predispositions might put them at high risk of suffering from heart dysfunction or cardiotoxicity during or after cancer treatment. 供应商 can then take steps with a heart protective agent or other therapy to prevent the damage.
“这一切都取决于病人. Cardio-oncology is about advancing our understanding of cardiovascular disease to help patients get through their cancer treatment safely and help them live longer, 高质量的生活,” Dr. 肯塔基州说.